Pub. Date : 1995 May
PMID : 7648206
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Hydrazine analogues have long been known to act as inactivators of PLP-dependent enzymes, including GABA aminotransferase, however, no studies of the molecular mechanism of inactivation of PLP-dependent enzymes by hydrazines have been reported. | hydrazine | 4-aminobutyrate aminotransferase | Sus scrofa |
2 | 3-Hydroxybenzylhydrazine is shown to be a potent in vitro time-dependent inhibitor of pig brain GABA aminotransferase. | 3-hydroxybenzylhydrazine | 4-aminobutyrate aminotransferase | Sus scrofa |
3 | UV-visible and 1H NMR studies, both with GABA aminotransferase and with PLP as a chemical model for the enzyme-catalyzed reaction, indicate that 3-hydroxybenzylhydrazine reacts both enzymatically and nonenzymatically to form the 3-hydroxybenzylhydrazone of PLP without tautomerization. | 3-hydroxybenzylhydrazine | 4-aminobutyrate aminotransferase | Sus scrofa |