Title : Time-dependent inhibition of gamma-aminobutyric acid aminotransferase, by 3-hydroxybenzylhydrazine.

Pub. Date : 1995 May

PMID : 7648206






3 Functional Relationships(s)
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1 Hydrazine analogues have long been known to act as inactivators of PLP-dependent enzymes, including GABA aminotransferase, however, no studies of the molecular mechanism of inactivation of PLP-dependent enzymes by hydrazines have been reported. hydrazine 4-aminobutyrate aminotransferase Sus scrofa
2 3-Hydroxybenzylhydrazine is shown to be a potent in vitro time-dependent inhibitor of pig brain GABA aminotransferase. 3-hydroxybenzylhydrazine 4-aminobutyrate aminotransferase Sus scrofa
3 UV-visible and 1H NMR studies, both with GABA aminotransferase and with PLP as a chemical model for the enzyme-catalyzed reaction, indicate that 3-hydroxybenzylhydrazine reacts both enzymatically and nonenzymatically to form the 3-hydroxybenzylhydrazone of PLP without tautomerization. 3-hydroxybenzylhydrazine 4-aminobutyrate aminotransferase Sus scrofa