Title : Role of CNP in human airways: cGMP-mediated stimulation of ciliary beat frequency.

Pub. Date : 1995 Jun

PMID : 7611424






10 Functional Relationships(s)
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1 Role of CNP in human airways: cGMP-mediated stimulation of ciliary beat frequency. Cyclic GMP natriuretic peptide C Homo sapiens
2 In a previous report, cGMP production in HAE was observed after stimulation with either C-type natriuretic peptide (CNP) or sodium nitroprusside (SNP) (6). Cyclic GMP natriuretic peptide C Homo sapiens
3 In a previous report, cGMP production in HAE was observed after stimulation with either C-type natriuretic peptide (CNP) or sodium nitroprusside (SNP) (6). Cyclic GMP natriuretic peptide C Homo sapiens
4 In this study, CNP was found to increase CBF by 30 +/- 6.9%, and this effect was mimicked by the cGMP analogue, 8-bromoguanosine 3",5"-cyclic monophosphate (8-BrcGMP), but not by sodium nitroprusside. Cyclic GMP natriuretic peptide C Homo sapiens
5 In this study, CNP was found to increase CBF by 30 +/- 6.9%, and this effect was mimicked by the cGMP analogue, 8-bromoguanosine 3",5"-cyclic monophosphate (8-BrcGMP), but not by sodium nitroprusside. 8-bromocyclic GMP natriuretic peptide C Homo sapiens
6 In this study, CNP was found to increase CBF by 30 +/- 6.9%, and this effect was mimicked by the cGMP analogue, 8-bromoguanosine 3",5"-cyclic monophosphate (8-BrcGMP), but not by sodium nitroprusside. 8-bromoguanosino-3',5'-cyclic monophosphorothioate natriuretic peptide C Homo sapiens
7 In this study, CNP was found to increase CBF by 30 +/- 6.9%, and this effect was mimicked by the cGMP analogue, 8-bromoguanosine 3",5"-cyclic monophosphate (8-BrcGMP), but not by sodium nitroprusside. Nitroprusside natriuretic peptide C Homo sapiens
8 Using modified Ussing chambers, we also investigated CNP"s potential modulation of sodium and chloride transport rates. Sodium natriuretic peptide C Homo sapiens
9 Using modified Ussing chambers, we also investigated CNP"s potential modulation of sodium and chloride transport rates. Chlorides natriuretic peptide C Homo sapiens
10 We conclude that CNP regulates ciliary beat via cGMP-dependent mechanisms, whereas no effect of CNP or cGMP on ion transport was detected. Cyclic GMP natriuretic peptide C Homo sapiens