Pub. Date : 1995 Jul
PMID : 7608264
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | HLA DQA1 and DQB1 alleles were defined by polymerase chain reaction and sequence-specific oligonucleotide hybridization as well as by single strand conformational polymorphism analysis. | Oligonucleotides | major histocompatibility complex, class II, DQ alpha 1 | Homo sapiens |
| 2 | An arginine at position 52 on either DQA1 allele was significantly more frequent in patients with IDDM (94%), GD (80%), and AD (89%) compared with controls (66%). | Arginine | major histocompatibility complex, class II, DQ alpha 1 | Homo sapiens |
| 3 | In conclusion, endocrine autoimmunity has a common immunogenetic background; susceptibility is conferred by DQA1*0501 as well as an arginine at position 52 of DQA1 alleles, and protection against IDDM and GD is conferred by DQB1*0602. | Arginine | major histocompatibility complex, class II, DQ alpha 1 | Homo sapiens |