Pub. Date : 1995 Nov 10
PMID : 7592963
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Transfection of COS.M6 cells with cardiac alpha 1C-a (alpha 1) led to the appearance of dihydropyridine ([3H]PN200-110) binding which was increased by coexpression of cardiac beta 2a (beta), alpha 2 delta a (alpha 2), and the skeletal muscle gamma. | 1,4-dihydropyridine | MGC75582, possible similarity to act2 S homeolog | Xenopus laevis |
| 2 | Transfection of COS.M6 cells with cardiac alpha 1C-a (alpha 1) led to the appearance of dihydropyridine ([3H]PN200-110) binding which was increased by coexpression of cardiac beta 2a (beta), alpha 2 delta a (alpha 2), and the skeletal muscle gamma. | 1,4-dihydropyridine | MGC75582, possible similarity to act2 S homeolog | Xenopus laevis |
| 3 | Transfection of COS.M6 cells with cardiac alpha 1C-a (alpha 1) led to the appearance of dihydropyridine ([3H]PN200-110) binding which was increased by coexpression of cardiac beta 2a (beta), alpha 2 delta a (alpha 2), and the skeletal muscle gamma. | Tritium | MGC75582, possible similarity to act2 S homeolog | Xenopus laevis |
| 4 | Transfection of COS.M6 cells with cardiac alpha 1C-a (alpha 1) led to the appearance of dihydropyridine ([3H]PN200-110) binding which was increased by coexpression of cardiac beta 2a (beta), alpha 2 delta a (alpha 2), and the skeletal muscle gamma. | Tritium | MGC75582, possible similarity to act2 S homeolog | Xenopus laevis |
| 5 | Therefore coexpression of alpha 1 beta and alpha 2 completely reconstituted high affinity dihydropyridine binding and its allosteric regulation as observed in cardiac membranes. | 1,4-dihydropyridine | MGC75582, possible similarity to act2 S homeolog | Xenopus laevis |
| 6 | Expression in Xenopus oocytes demonstrated that coexpression of alpha 2 with alpha 1 beta increased the potency and maximum extent of block of Ca2+ channel currents by nisoldipine, a dihydropyridine Ca2+ channel antagonist. | Nisoldipine | MGC75582, possible similarity to act2 S homeolog | Xenopus laevis |