Pub. Date : 1995 Jun
PMID : 7560859
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Maximum biliary outputs of alkaline phosphatase and gamma-glutamyl transpeptidase were significantly increased in the ethynylestradiol group during infusion of sodium taurocholate and taurochenodeoxycholate, but not of tauroursodeoxycholate, and were increased in the complete biliary obstruction group during the infusion of sodium taurocholate and tauroursodeoxycholate but not of taurochenodeoxycholate. | Taurochenodeoxycholic Acid | gamma-glutamyltransferase 1 | Rattus norvegicus |
| 2 | The biliary outputs of alkaline phosphatase and gamma-glutamyl transpeptidase showed a significant and direct linear relationship with sodium taurocholate and taurochenodeoxycholate secretory rates in both cholestatic groups. | Taurochenodeoxycholic Acid | gamma-glutamyltransferase 1 | Rattus norvegicus |
| 3 | The slope of the line, which indicated the mU of enzyme activity secreted per nmol of sodium taurocholate or taurochenodeoxycholate, was greater for gamma-glutamyl transpeptidase and alkaline phosphatase in both cholestatic groups (ethynylestradiol > complete biliary obstruction) than in the control group. | Taurochenodeoxycholic Acid | gamma-glutamyltransferase 1 | Rattus norvegicus |
| 4 | CONCLUSION: The marked increase in sodium taurocholate and taurochenodeoxycholate-mediated release of alkaline phosphatase and gamma-glutamyl transpeptidase into bile in cholestatic rats suggests an increased lability of these intrinsic membrane proteins to the detergent effects of secreted bile acids. | Taurochenodeoxycholic Acid | gamma-glutamyltransferase 1 | Rattus norvegicus |