Title : The thrombopoietin receptor c-MPL activates JAK2 and TYK2 tyrosine kinases.

Pub. Date : 1995 Aug

PMID : 7543416






2 Functional Relationships(s)
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1 The activation of both JAK2 and TYK2 was dose- and time-dependent and was associated with rapid tyrosine phosphorylation of a series of STAT proteins including STAT1, STAT3, and STAT5. Tyrosine Janus kinase 2 Homo sapiens
2 In this study, we found that activation of the TPO receptor rapidly induced tyrosine phosphorylation of two members of the Jak tyrosine kinase family, JAK2 and TYK2, but not JAK1 or JAK3, in two different factor-dependent hematopoietic cell lines. Tyrosine Janus kinase 2 Homo sapiens