Title : Cytokines activate inducible nitric oxide synthase gene transcription in inner medullary collecting duct cells.

Pub. Date : 1995 Apr

PMID : 7537467






6 Functional Relationships(s)
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Protein Name
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1 The induction of nitrite production and iNOS mRNA was time dependent, requiring approximately 8 h for expression of significant levels of nitrite or iNOS mRNA. Nitrites nitric oxide synthase 2, inducible Mus musculus
2 The induction of nitrite production and iNOS mRNA was time dependent, requiring approximately 8 h for expression of significant levels of nitrite or iNOS mRNA. Nitrites nitric oxide synthase 2, inducible Mus musculus
3 Coincubation with the transcription inhibitor actinomycin D or the translation inhibitor cycloheximide prevented the cytokine induction of iNOS mRNA and NO production, indicating that synthesis of intermediary proteins stimulated transcription of the iNOS gene. Dactinomycin nitric oxide synthase 2, inducible Mus musculus
4 Coincubation with the transcription inhibitor actinomycin D or the translation inhibitor cycloheximide prevented the cytokine induction of iNOS mRNA and NO production, indicating that synthesis of intermediary proteins stimulated transcription of the iNOS gene. Dactinomycin nitric oxide synthase 2, inducible Mus musculus
5 Coincubation with the transcription inhibitor actinomycin D or the translation inhibitor cycloheximide prevented the cytokine induction of iNOS mRNA and NO production, indicating that synthesis of intermediary proteins stimulated transcription of the iNOS gene. Cycloheximide nitric oxide synthase 2, inducible Mus musculus
6 Coincubation with the transcription inhibitor actinomycin D or the translation inhibitor cycloheximide prevented the cytokine induction of iNOS mRNA and NO production, indicating that synthesis of intermediary proteins stimulated transcription of the iNOS gene. Cycloheximide nitric oxide synthase 2, inducible Mus musculus