Title : Vesicle membrane association of nitric oxide synthase in primary mouse macrophages.

Pub. Date : 1995 Mar 15

PMID : 7533187






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Vesicular iNOS arose from cytosolic iNOS by undergoing a post-translational modification that increased its apparent molecular mass by 4.5 kDa and promoted its salt-, detergent-, acid- and urea-resistant association with membranes, in the absence of detectable alternative splicing, myristoylation, palmitoylation, acetylation, glycosylation, or COOH-terminal truncation. Urea nitric oxide synthase 2, inducible Mus musculus
2 Vesicular iNOS arose from cytosolic iNOS by undergoing a post-translational modification that increased its apparent molecular mass by 4.5 kDa and promoted its salt-, detergent-, acid- and urea-resistant association with membranes, in the absence of detectable alternative splicing, myristoylation, palmitoylation, acetylation, glycosylation, or COOH-terminal truncation. Urea nitric oxide synthase 2, inducible Mus musculus
3 Although primary macrophage iNOS underwent phosphorylation, ubiquitinylation, and binding of calmodulin tightly enough to resist boiling in SDS, these modifications did not allow us to distinguish between the cytosolic and particulate variants. Sodium Dodecyl Sulfate nitric oxide synthase 2, inducible Mus musculus