Title : Chemokines of the alpha, beta-subclass inhibit human basophils' responsiveness to monocyte chemotactic and activating factor/monocyte chemoattractant protein-1.

Pub. Date : 1995 Feb

PMID : 7531729






5 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Monocyte chemotactic and activating factor (MCAF) is the most potent cytokine that activates basophils to release histamine. Histamine C-C motif chemokine ligand 2 Homo sapiens
2 Monocyte chemotactic and activating factor (MCAF) is the most potent cytokine that activates basophils to release histamine. Histamine C-C motif chemokine ligand 2 Homo sapiens
3 Simultaneous addition of MCAF and any of the chemokines studied evoked an augmented response as measured by histamine release, whereas preincubation of leukocytes or purified basophils (80%) with these chemokines decreased MCAF-induced histamine release in a dose-dependent manner. Histamine C-C motif chemokine ligand 2 Homo sapiens
4 Simultaneous addition of MCAF and any of the chemokines studied evoked an augmented response as measured by histamine release, whereas preincubation of leukocytes or purified basophils (80%) with these chemokines decreased MCAF-induced histamine release in a dose-dependent manner. Histamine C-C motif chemokine ligand 2 Homo sapiens
5 We have therefore characterized RANTES, MIP-1 alpha, MIP-1 beta, CTAP III, PF4, IL-8, and IP-10 as inhibitors of MCAF-induced histamine release. Histamine C-C motif chemokine ligand 2 Homo sapiens