Pub. Date : 1995 Feb
PMID : 7531729
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Monocyte chemotactic and activating factor (MCAF) is the most potent cytokine that activates basophils to release histamine. | Histamine | C-C motif chemokine ligand 2 | Homo sapiens |
2 | Monocyte chemotactic and activating factor (MCAF) is the most potent cytokine that activates basophils to release histamine. | Histamine | C-C motif chemokine ligand 2 | Homo sapiens |
3 | Simultaneous addition of MCAF and any of the chemokines studied evoked an augmented response as measured by histamine release, whereas preincubation of leukocytes or purified basophils (80%) with these chemokines decreased MCAF-induced histamine release in a dose-dependent manner. | Histamine | C-C motif chemokine ligand 2 | Homo sapiens |
4 | Simultaneous addition of MCAF and any of the chemokines studied evoked an augmented response as measured by histamine release, whereas preincubation of leukocytes or purified basophils (80%) with these chemokines decreased MCAF-induced histamine release in a dose-dependent manner. | Histamine | C-C motif chemokine ligand 2 | Homo sapiens |
5 | We have therefore characterized RANTES, MIP-1 alpha, MIP-1 beta, CTAP III, PF4, IL-8, and IP-10 as inhibitors of MCAF-induced histamine release. | Histamine | C-C motif chemokine ligand 2 | Homo sapiens |