Pub. Date : 1995 Jan
PMID : 7530281
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nitric oxide (NO), a potent and versatile free radical, is synthesized in macrophages and mast cells as well as in other types of cells by the inducible form of nitric oxide synthase (iNOS). | Nitric Oxide | nitric oxide synthase 2, inducible | Mus musculus |
| 2 | Because cyclic variations suggested regulation of iNOS expression by ovarian steroid hormones, studies were done using ovariectomized mice. | Steroids | nitric oxide synthase 2, inducible | Mus musculus |
| 3 | In the uteri of ovariectomized, estradiol-17 beta (E2)-treated mice, mast cells were iNOS+ after 24 h whereas epithelial cells were negative; the reverse was observed in progesterone (P4)-treated mice. | estradiol-17 beta (e2) | nitric oxide synthase 2, inducible | Mus musculus |
| 4 | Both mast cells and epithelial cells were iNOS+ in the uteri of mice that had received a combination of E2 + P4. | e2 + p4 | nitric oxide synthase 2, inducible | Mus musculus |
| 5 | These results indicate that several types of uterine cells produce iNOS and that expression of this enzyme in specific cell lineages is governed by ovarian steroid hormones. | Steroids | nitric oxide synthase 2, inducible | Mus musculus |