Pub. Date : 1994 Apr 15
PMID : 7511667
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Large amounts of nitric oxide (NO) are produced by the inducible isoform of NO synthase (iNOS) in many cell types once the iNOS gene is transcriptionally activated. | Nitric Oxide | nitric oxide synthase 2, inducible | Mus musculus |
| 2 | Large amounts of nitric oxide (NO) are produced by the inducible isoform of NO synthase (iNOS) in many cell types once the iNOS gene is transcriptionally activated. | Nitric Oxide | nitric oxide synthase 2, inducible | Mus musculus |
| 3 | In primary mouse peritoneal macrophages elicited by thioglycolate broth, expression of iNOS follows treatment with IFN-gamma and is synergistically increased by the addition of bacterial LPS. | thioglycolate broth | nitric oxide synthase 2, inducible | Mus musculus |
| 4 | Mouse peritoneal macrophages cultured in the presence of IFN-gamma alone or IFN-gamma plus LPS rapidly depleted the medium of L-arginine, a substrate for iNOS, and stopped producing NO. | Arginine | nitric oxide synthase 2, inducible | Mus musculus |
| 5 | L-Arginine repletion also boosted NO production by macrophages cultured for up to 2 to 3 days in the presence of IFN-gamma plus LPS, but thereafter, iNOS was inactive in these cells whether or not L-arginine was repleted. | Arginine | nitric oxide synthase 2, inducible | Mus musculus |
| 6 | Activity of iNOS could be restored by adding both L-arginine and fresh IFN-gamma with or without LPS, likely reflecting the synthesis of new enzyme. | Arginine | nitric oxide synthase 2, inducible | Mus musculus |