Title : The novel cyclic dinucleotide 3'-5' cyclic diguanylic acid binds to p21ras and enhances DNA synthesis but not cell replication in the Molt 4 cell line.

Pub. Date : 1995 Nov 1

PMID : 7487952






1 Functional Relationships(s)
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1 The effects described appear to be unique for c-di-GMP and, taken together, raise the possibility that an irreversible binding of this guanine nucleotide to the growth-promoting p21ras protein results in a fixed active conformation of this protein affecting DNA synthesis. bis(3',5')-cyclic diguanylic acid HRas proto-oncogene, GTPase Homo sapiens