Title : Deaths from local anesthetic-induced convulsions in mice.

Pub. Date : 1980 Jun

PMID : 7189975






2 Functional Relationships(s)
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1 The CD50 and LD50, respectively, were 57.7 and 58.7 mg/kg for bupivacaine, 111.0 and 133.1 mg/kg for lidocaine, and 243.4 and 266.5 mg/kg for chloroprocaine. Bupivacaine intercellular adhesion molecule 5, telencephalin Mus musculus
2 A CD50 dose of local anesthetic (causing convulsions in 50% of mice) was fatal in 90% of bupivacaine-induced seizures, in 57% of the chloroprocaine group, and in 6% of the lidocaine group. Bupivacaine intercellular adhesion molecule 5, telencephalin Mus musculus