Title : Resistance to 6-thioguanine in spontaneously cycling and in mitogen-stimulated human peripheral lymphocytes.

Pub. Date : 1984 Jan

PMID : 6690915






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In PHA-stimulated samples from the same persons the frequency of 6-thioguanine (TG)-resistant variants was between 4 X 10(-7) and 2.6 X 10(-6), which indicates that most of the spontaneously cycling cells were TG-sensitive. Thioguanine lamin B receptor Homo sapiens
2 In PHA-stimulated samples from the same persons the frequency of 6-thioguanine (TG)-resistant variants was between 4 X 10(-7) and 2.6 X 10(-6), which indicates that most of the spontaneously cycling cells were TG-sensitive. Thioguanine lamin B receptor Homo sapiens
3 With lymphocytes from one of the referents it was found that: (i) in the presence of 2 X 10(-4) M TG, more than 97% of the spontaneously cycling cells were inhibited before or in early S phase, and (ii) when a flow cytometer was set to sort out TG-resistant cells in late S + G2 phase after 48 h incubation in medium with PHA, the contribution of TG-resistant cells from the spontaneously cycling fraction amounted to less than 2% of the total number of resistant cells. Thioguanine lamin B receptor Homo sapiens