Title : Metabolic resistance to tight-binding inhibitors of enzymes involved in the de novo pyrimidine pathway. Simulation of time-dependent effects.

Pub. Date : 1984 Aug 15

PMID : 6468388






10 Functional Relationships(s)
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1 In addition we present a simulation of the expected effect in vivo of phosphoribofuranosyl barbituric acid (BMP), a tight-binding inhibitor of OMP decarboxylase [H. L. Levine, R. S. Brody, and F. H. Westheimer (1980) Biochemistry 19, 4993- 4999]. 1-(5'-phospho-beta-D-ribofuranosyl)barbituric acid bone morphogenetic protein 1 Homo sapiens
2 This simulation shows that on addition of BMP, there is a sequential depletion of all pyrimidine intermediates between UMP and dCDP and a concomitant accumulation of OMP. pyrimidine bone morphogenetic protein 1 Homo sapiens
3 This simulation shows that on addition of BMP, there is a sequential depletion of all pyrimidine intermediates between UMP and dCDP and a concomitant accumulation of OMP. Uridine Monophosphate bone morphogenetic protein 1 Homo sapiens
4 This simulation shows that on addition of BMP, there is a sequential depletion of all pyrimidine intermediates between UMP and dCDP and a concomitant accumulation of OMP. 2'-deoxycytidine diphosphate bone morphogenetic protein 1 Homo sapiens
5 We have simulated the depletion of dCDP at various concentrations of BMP; since dCDP is comitted to DNA synthesis we can integrate the dCDP concentrations over time to calculate the amount of DNA synthesis and thereby predict the delay in cell division which would be elicited by BMP. 2'-deoxycytidine diphosphate bone morphogenetic protein 1 Homo sapiens
6 We have simulated the depletion of dCDP at various concentrations of BMP; since dCDP is comitted to DNA synthesis we can integrate the dCDP concentrations over time to calculate the amount of DNA synthesis and thereby predict the delay in cell division which would be elicited by BMP. 2'-deoxycytidine diphosphate bone morphogenetic protein 1 Homo sapiens
7 We have simulated the depletion of dCDP at various concentrations of BMP; since dCDP is comitted to DNA synthesis we can integrate the dCDP concentrations over time to calculate the amount of DNA synthesis and thereby predict the delay in cell division which would be elicited by BMP. 2'-deoxycytidine diphosphate bone morphogenetic protein 1 Homo sapiens
8 We have simulated the depletion of dCDP at various concentrations of BMP; since dCDP is comitted to DNA synthesis we can integrate the dCDP concentrations over time to calculate the amount of DNA synthesis and thereby predict the delay in cell division which would be elicited by BMP. 2'-deoxycytidine diphosphate bone morphogenetic protein 1 Homo sapiens
9 We have simulated the depletion of dCDP at various concentrations of BMP; since dCDP is comitted to DNA synthesis we can integrate the dCDP concentrations over time to calculate the amount of DNA synthesis and thereby predict the delay in cell division which would be elicited by BMP. 2'-deoxycytidine diphosphate bone morphogenetic protein 1 Homo sapiens
10 We have simulated the depletion of dCDP at various concentrations of BMP; since dCDP is comitted to DNA synthesis we can integrate the dCDP concentrations over time to calculate the amount of DNA synthesis and thereby predict the delay in cell division which would be elicited by BMP. 2'-deoxycytidine diphosphate bone morphogenetic protein 1 Homo sapiens