Pub. Date : 1983 Mar 22
PMID : 6299366
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Acyl-CoA inhibition of hydroxymethylglutaryl-CoA reductase as well as methyl sterol oxidase can be either prevented or reversed by the addition of purified Z-protein (fatty acid-binding protein). | Fatty Acids | transmembrane BAX inhibitor motif containing 4 | Homo sapiens |
| 2 | Concomitantly, Z-protein addition decreases the extent of binding of radioactively labeled oleoyl-CoA to microsomal membranes. | oleoyl-coenzyme A | transmembrane BAX inhibitor motif containing 4 | Homo sapiens |
| 3 | Free heme also inhibits hydroxymethylglutaryl-CoA reductase, and Z-protein reverses the extent of observed inhibition by binding heme analogous to the effect observed with acyl-CoAs. | Heme | transmembrane BAX inhibitor motif containing 4 | Homo sapiens |
| 4 | Free heme also inhibits hydroxymethylglutaryl-CoA reductase, and Z-protein reverses the extent of observed inhibition by binding heme analogous to the effect observed with acyl-CoAs. | Coenzyme A | transmembrane BAX inhibitor motif containing 4 | Homo sapiens |
| 5 | All these observations are consistent with the suggestion that, by binding acyl-CoAs and other enzyme effectors such as free heme, Z-protein modulates the effects of fluctuations of concentrations of major cellular metabolites. | Heme | transmembrane BAX inhibitor motif containing 4 | Homo sapiens |
| 6 | Furthermore, because the concentration of Z-protein is very low in rapidly growing hepatomas, such tumors may be very poorly buffered against the effects of acyl-CoAs, free fatty acids, heme and other effectors that may vary markedly by either altered metabolism or release of metabolites from necrotic tumor tissue. | Acyl Coenzyme A | transmembrane BAX inhibitor motif containing 4 | Homo sapiens |
| 7 | Furthermore, because the concentration of Z-protein is very low in rapidly growing hepatomas, such tumors may be very poorly buffered against the effects of acyl-CoAs, free fatty acids, heme and other effectors that may vary markedly by either altered metabolism or release of metabolites from necrotic tumor tissue. | Fatty Acids, Nonesterified | transmembrane BAX inhibitor motif containing 4 | Homo sapiens |
| 8 | Furthermore, because the concentration of Z-protein is very low in rapidly growing hepatomas, such tumors may be very poorly buffered against the effects of acyl-CoAs, free fatty acids, heme and other effectors that may vary markedly by either altered metabolism or release of metabolites from necrotic tumor tissue. | Heme | transmembrane BAX inhibitor motif containing 4 | Homo sapiens |