Title : Effect of serotonin antagonists on the dextran-induced anaphylactoid reaction in the rat.

Pub. Date : 1981 May

PMID : 6175173






3 Functional Relationships(s)
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1 Dextran injected intravenously into rats causes a rapid lowering of the extent of activation of factor XII and of the plasma levels of prekallikrein and plasminogen, and at the same time a profound fall in blood pressure. Dextrans coagulation factor XII Rattus norvegicus
2 All three serotonin antagonists showed a serotonin-like lowering effect on the activation of factor XII and on the level of prekallikrein in plasma (BOL 148 1.0-4.0 mg/kg; methysergide 0.10-0.60 mg/kg; ergotamine 0.10-0.60 mg/kg). Serotonin coagulation factor XII Rattus norvegicus
3 All three serotonin antagonists showed a serotonin-like lowering effect on the activation of factor XII and on the level of prekallikrein in plasma (BOL 148 1.0-4.0 mg/kg; methysergide 0.10-0.60 mg/kg; ergotamine 0.10-0.60 mg/kg). Serotonin coagulation factor XII Rattus norvegicus