Title : Effects of selective and non-selective beta-adrenergic agents on insulin secretion in vivo.

Pub. Date : 1981 Apr 24

PMID : 6113155






3 Functional Relationships(s)
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1 The non-selective beta-stimulator isopropylnoradrenaline and the selective beta 2-stimulator terbutaline both stimulated insulin secretion markedly, with the same efficacy and in a dose-dependent manner. Terbutaline hemoglobin, beta adult minor chain Mus musculus
2 At very high dose levels the beta 2-stimulator isopropylaminothiazoloxypropanol slightly increased plasma insulin concentrations. isopropylaminothiazoloxypropanol hemoglobin, beta adult minor chain Mus musculus
3 The non-selective beta-blocker propranolol and the beta 2-selective blocker ICI 188,551 inhibited terbutaline-induced insulin release markedly and at comparable low dose levels, whereas the selective beta 1-blocker metoprolol exerted this effect only at a high dose level. Terbutaline hemoglobin, beta adult minor chain Mus musculus