Title : Control of the citric acid cycle by glyoxylate. The mechanism of inhibition of oxoglutarate dehydrogenase, isocitrate dehydrogenase and aconitate hydratase.

Pub. Date : 1969 Sep

PMID : 5820638






2 Functional Relationships(s)
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1 Glyoxylate (0.025mm) inhibited oxoglutarate dehydrogenase irreversibly, whereas the same concentrations of oxalomalate and hydroxyoxoglutarate were ineffective. glyoxylic acid oxoglutarate dehydrogenase Homo sapiens
2 The behaviour of glyoxylate in producing multiple inhibitions of the citric acid cycle, either by direct interaction with oxoglutarate dehydrogenase, or by means of its condensation compounds which inhibit aconitate hydratase and isocitrate dehydrogenase, is discussed. glyoxylic acid oxoglutarate dehydrogenase Homo sapiens