Title : Extent of formation of O4-methylthymidine in calf thymus DNA methylated by N-methyl-N-nitrosourea and lack of repair of this product by rat liver O6-alkylguanine-DNA-alkyltransferase.

Pub. Date : 1985 Nov

PMID : 4053281






3 Functional Relationships(s)
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1 The E. coli O6-alkylguanine-DNA-alkyltransferase also removed 89% of the O4-methylthymidine but the rat liver alkyltransferase did not alter the content of O4-methylthymidine. O-methylthymidine O-6-methylguanine-DNA methyltransferase Rattus norvegicus
2 These results indicate that the mammalian O6-alkylguanine-DNA-alkyltransferase is specific for O6-methylguanine and differs from the bacterial protein in that it does not demethylate O4-methylthymine at any significant rate. O-(6)-methylguanine O-6-methylguanine-DNA methyltransferase Rattus norvegicus
3 These results indicate that the mammalian O6-alkylguanine-DNA-alkyltransferase is specific for O6-methylguanine and differs from the bacterial protein in that it does not demethylate O4-methylthymine at any significant rate. O-4-methylthymine O-6-methylguanine-DNA methyltransferase Rattus norvegicus