Pub. Date : 1985 Oct 1
PMID : 4052095
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In vivo and in vitro inhibition of human histidine decarboxylase by (S)-alpha-fluoromethylhistidine. | alpha-fluoromethylhistidine | histidine decarboxylase | Homo sapiens |
| 2 | Histidine decarboxylase (HDC) activity in Ficoll-Hypaque purified human peripheral blood leukocytes (PBL) was determined by measuring the formation of [3H]histamine from L-[3H]histidine. | Histamine | histidine decarboxylase | Homo sapiens |
| 3 | Histidine decarboxylase (HDC) activity in Ficoll-Hypaque purified human peripheral blood leukocytes (PBL) was determined by measuring the formation of [3H]histamine from L-[3H]histidine. | Histamine | histidine decarboxylase | Homo sapiens |
| 4 | Histidine decarboxylase (HDC) activity in Ficoll-Hypaque purified human peripheral blood leukocytes (PBL) was determined by measuring the formation of [3H]histamine from L-[3H]histidine. | l-[3h]histidine | histidine decarboxylase | Homo sapiens |
| 5 | Histidine decarboxylase (HDC) activity in Ficoll-Hypaque purified human peripheral blood leukocytes (PBL) was determined by measuring the formation of [3H]histamine from L-[3H]histidine. | l-[3h]histidine | histidine decarboxylase | Homo sapiens |
| 6 | HDC activity was inhibited in vitro to more than 90% by (S)-alpha-fluoromethylhistidine (alpha-FMH) at concentrations of 10(-5) M and above. | alpha-fluoromethylhistidine | histidine decarboxylase | Homo sapiens |
| 7 | HDC activity was inhibited in vitro to more than 90% by (S)-alpha-fluoromethylhistidine (alpha-FMH) at concentrations of 10(-5) M and above. | alpha-fluoromethylhistidine | histidine decarboxylase | Homo sapiens |
| 8 | A dose-dependent inhibition of HDC activity was observed in PBL that were isolated both at 12 hr after administration of the first dose of alpha-FMH and after treatment for 1 week. | alpha-fluoromethylhistidine | histidine decarboxylase | Homo sapiens |
| 9 | At the 50 and 100 mg doses of alpha-FMH, there was complete inhibition of HDC activity and partial inhibition at the 10 mg dose. | alpha-fluoromethylhistidine | histidine decarboxylase | Homo sapiens |
| 10 | Twenty-four hours after the last dose, HDC activity had recovered to 64-100%, 44-46%, and 30-52% of control values in subjects that received 10, 50 and 100 mg alpha-FMH respectively. | alpha-fluoromethylhistidine | histidine decarboxylase | Homo sapiens |