Pub. Date : 2022 Winter
PMID : 35611249
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effects of valproic acid on SOCS-1, SOCS-2, SOCS-3, SOCS-5, SOCS6, and SOCS-7 gene expression and cell growth inhibition in colon carcinoma. | Valproic Acid | suppressor of cytokine signaling 5 | Homo sapiens |
| 2 | Aim: The current study aimed to investigate the effect of valproic acid (VPA) on SOCS-1, SOCS-2, SOCS-3, SOCS-5, SOCS6, and SOCS-7 gene expression and cell growth inhibition in colon carcinoma IS1, IS2, and IS3 cell lines. | Valproic Acid | suppressor of cytokine signaling 5 | Homo sapiens |
| 3 | Results: VPA changed the expression levels of the SOCS-1, SOCS-2, SOCS-3, SOCS-5, SOCS6, and SOCS-7 genes, by which cell apoptosis was induced and cell growth inhibited in all three cell lines (p < 0.0001). | Valproic Acid | suppressor of cytokine signaling 5 | Homo sapiens |
| 4 | Conclusion: VPA can induce apoptosis through reactivation of SOCS-1, SOCS-2, SOCS-3, SOCS-5, SOCS6, and SOCS-7 gene expression. | Valproic Acid | suppressor of cytokine signaling 5 | Homo sapiens |