Title : Valproic acid modulates collagen architecture in the postoperative conjunctival scar.

Pub. Date : 2022 Jun

PMID : 35583819






4 Functional Relationships(s)
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1 At the molecular level, VPA reduced Col1a1 but induced Matn2, Matn3, and Matn4 in the postoperative day 7 conjunctival tissue. Valproic Acid matrilin 2 Homo sapiens
2 In primary conjunctival fibroblasts, Matn2 expression was resistant to both VPA and TGF-beta2, Matn3 was sensitive to both VPA and TGF-beta2 individually and synergistically, while Matn4 was modulable by VPA but not TGF-beta2. Valproic Acid matrilin 2 Homo sapiens
3 In primary conjunctival fibroblasts, Matn2 expression was resistant to both VPA and TGF-beta2, Matn3 was sensitive to both VPA and TGF-beta2 individually and synergistically, while Matn4 was modulable by VPA but not TGF-beta2. Valproic Acid matrilin 2 Homo sapiens
4 VPA induces MATN2, MATN3, and MATN4 in the postoperative scar. Valproic Acid matrilin 2 Homo sapiens