Pub. Date : 2022 Aug
PMID : 35470044
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cyp2c70-/- mice with a human-like bile acid (BA) composition, lacking hydrophilic muricholic acids (MCAs), have been reported to display cholangiopathy and biliary fibrosis with female preponderance that can be reversed by ursodeoxycholic acid (UDCA). | Bile Acids and Salts | cytochrome P450, family 2, subfamily c, polypeptide 70 | Mus musculus |
| 2 | Cyp2c70-/- mice with a human-like bile acid (BA) composition, lacking hydrophilic muricholic acids (MCAs), have been reported to display cholangiopathy and biliary fibrosis with female preponderance that can be reversed by ursodeoxycholic acid (UDCA). | Bile Acids and Salts | cytochrome P450, family 2, subfamily c, polypeptide 70 | Mus musculus |
| 3 | Cyp2c70-/- mice with a human-like bile acid (BA) composition, lacking hydrophilic muricholic acids (MCAs), have been reported to display cholangiopathy and biliary fibrosis with female preponderance that can be reversed by ursodeoxycholic acid (UDCA). | muricholic acid | cytochrome P450, family 2, subfamily c, polypeptide 70 | Mus musculus |
| 4 | Cyp2c70-/- mice with a human-like bile acid (BA) composition, lacking hydrophilic muricholic acids (MCAs), have been reported to display cholangiopathy and biliary fibrosis with female preponderance that can be reversed by ursodeoxycholic acid (UDCA). | Ursodeoxycholic Acid | cytochrome P450, family 2, subfamily c, polypeptide 70 | Mus musculus |
| 5 | Cyp2c70-/- mice with a human-like bile acid (BA) composition, lacking hydrophilic muricholic acids (MCAs), have been reported to display cholangiopathy and biliary fibrosis with female preponderance that can be reversed by ursodeoxycholic acid (UDCA). | Ursodeoxycholic Acid | cytochrome P450, family 2, subfamily c, polypeptide 70 | Mus musculus |
| 6 | In Cyp2c70-/- mice, however, BA pool became more hydrophobic with a larger proportion of chenodeoxycholic acid, attributable to a reduction of BA 12alpha-hydroxylation. | Bile Acids and Salts | cytochrome P450, family 2, subfamily c, polypeptide 70 | Mus musculus |
| 7 | In Cyp2c70-/- mice, however, BA pool became more hydrophobic with a larger proportion of chenodeoxycholic acid, attributable to a reduction of BA 12alpha-hydroxylation. | Chenodeoxycholic Acid | cytochrome P450, family 2, subfamily c, polypeptide 70 | Mus musculus |
| 8 | In Cyp2c70-/- mice, however, BA pool became more hydrophobic with a larger proportion of chenodeoxycholic acid, attributable to a reduction of BA 12alpha-hydroxylation. | Bile Acids and Salts | cytochrome P450, family 2, subfamily c, polypeptide 70 | Mus musculus |
| 9 | In conclusion, 4 weeks of OCA treatment oppositely modulates the hydrophobicity of the BA pool in WT and Cyp2c70-/- mice, but does not improve or worsen the characteristic sex-dependent liver pathology in Cyp2c70-/- mice. | obeticholic acid | cytochrome P450, family 2, subfamily c, polypeptide 70 | Mus musculus |
| 10 | In conclusion, 4 weeks of OCA treatment oppositely modulates the hydrophobicity of the BA pool in WT and Cyp2c70-/- mice, but does not improve or worsen the characteristic sex-dependent liver pathology in Cyp2c70-/- mice. | Bile Acids and Salts | cytochrome P450, family 2, subfamily c, polypeptide 70 | Mus musculus |