Pub. Date : 2022 Jun
PMID : 35405616
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Discovery of oridonin as a novel agonist for BRS-3. | oridonin | bombesin-like receptor 3 | Mus musculus |
| 2 | Recent studies have shown that BRS-3 played a vital role in glucose regulation, insulin secretion, and energy homeostasis. | Glucose | bombesin-like receptor 3 | Mus musculus |
| 3 | To further validate the target of BRS-3, a series of in vitro and in vivo experiences were conducted, including glucose uptake, glucose transporter type 4 (GLUT4) transportation in C2C12, and oral glucose tolerance test (OGTT) in mice. | Glucose | bombesin-like receptor 3 | Mus musculus |
| 4 | To further validate the target of BRS-3, a series of in vitro and in vivo experiences were conducted, including glucose uptake, glucose transporter type 4 (GLUT4) transportation in C2C12, and oral glucose tolerance test (OGTT) in mice. | Glucose | bombesin-like receptor 3 | Mus musculus |
| 5 | RESULTS: We discovered and identified oridonin as a novel small molecule agonist of BRS-3, with a moderate affinity (EC50 of 2.236 x 10-7 M in calcium mobilization assay), specificity, and subtype selectivity. | oridonin | bombesin-like receptor 3 | Mus musculus |
| 6 | Further in vitro and in vivo tests demonstrated that oridonin exerted beneficial effects in glucose homeostasis through activating BRS-3. | oridonin | bombesin-like receptor 3 | Mus musculus |
| 7 | Further in vitro and in vivo tests demonstrated that oridonin exerted beneficial effects in glucose homeostasis through activating BRS-3. | Glucose | bombesin-like receptor 3 | Mus musculus |
| 8 | CONCLUSIONS: Oridonin, as the discovered new ligand of BRS-3, provides a valuable tool compound to investigate BRS-3"s function, especially for target validation in type 2 diabetes and obesity. | oridonin | bombesin-like receptor 3 | Mus musculus |
| 9 | CONCLUSIONS: Oridonin, as the discovered new ligand of BRS-3, provides a valuable tool compound to investigate BRS-3"s function, especially for target validation in type 2 diabetes and obesity. | oridonin | bombesin-like receptor 3 | Mus musculus |