Title : Nrf2-mediated induction of Cyp2a5 partially protects against reductive endoplasmic reticulum stress in mouse hepatocytes.

Pub. Date : 2022 Mar 25

PMID : 35341795






2 Functional Relationships(s)
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1 We previously showed that mouse hepatic Cyp2a5 is induced during reductive ER stress caused by the intramolecular disulfide form of dithiothreitol, trans-4,5-dihydroxy-1,2-dithiane (DTTox), and that overexpression of Cyp2a5 provides partial protection against apoptosis due to bilirubin (BR), a compound known to cause ER stress. dithiane-4,5-diol cytochrome P450, family 2, subfamily a, polypeptide 5 Mus musculus
2 We previously showed that mouse hepatic Cyp2a5 is induced during reductive ER stress caused by the intramolecular disulfide form of dithiothreitol, trans-4,5-dihydroxy-1,2-dithiane (DTTox), and that overexpression of Cyp2a5 provides partial protection against apoptosis due to bilirubin (BR), a compound known to cause ER stress. dithiane-4,5-diol cytochrome P450, family 2, subfamily a, polypeptide 5 Mus musculus