Pub. Date : 2022 Mar 15
PMID : 35292636
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Hepatic stellate cell mediates transcription of TNFSF14 in hepatocellular carcinoma cells via H2S/CSE-JNK/JunB signaling pathway. | Deuterium | TNF superfamily member 14 | Homo sapiens |
| 2 | RNA-sequencing, RT-qPCR, and Western blotting results showed that TNFSF14 gene was upregulated in both LX-2 and NaHS group. | sodium bisulfide | TNF superfamily member 14 | Homo sapiens |
| 3 | NaHS treated in HCC cells led to JNK/JunB signaling pathway activating and greater binding of p-JunB to its responsive elements on TNFSF14 promoter. | sodium bisulfide | TNF superfamily member 14 | Homo sapiens |
| 4 | Impairment of TNFSF14 induction alleviated LX-2 and NaHS induced apoptosis of HepG2 and PLC/PRF/5 cells. | sodium bisulfide | TNF superfamily member 14 | Homo sapiens |
| 5 | In summary, demonstration of the involvement of HSC-derived H2S in JNK/JunB mediated expression of TNFSF14 gene strongly indicates H2S palys an important role in the regulation of HCC apoptosis. | Deuterium | TNF superfamily member 14 | Homo sapiens |
| 6 | In summary, demonstration of the involvement of HSC-derived H2S in JNK/JunB mediated expression of TNFSF14 gene strongly indicates H2S palys an important role in the regulation of HCC apoptosis. | Deuterium | TNF superfamily member 14 | Homo sapiens |