Title : Linc-RAM promotes muscle cell differentiation via regulating glycogen phosphorylase activity.

Pub. Date : 2022 Mar 7

PMID : 35254536






5 Functional Relationships(s)
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1 We report here that Linc-RAM physically interacts with glycogen phosphorylase (PYGM) in the cytoplasm. linc-ram glycogen phosphorylase, muscle associated Homo sapiens
2 Knockdown of PYGM significantly attenuates the function of Linc-RAM in promoting muscle cell differentiation. linc-ram glycogen phosphorylase, muscle associated Homo sapiens
3 Finally, we show that the interaction between Linc-RAM and PYGM positively regulates the enzymatic activity of PYGM in muscle cells. linc-ram glycogen phosphorylase, muscle associated Homo sapiens
4 Finally, we show that the interaction between Linc-RAM and PYGM positively regulates the enzymatic activity of PYGM in muscle cells. linc-ram glycogen phosphorylase, muscle associated Homo sapiens
5 Collectively, our findings unveil a molecular mechanism through which cytoplasmic Linc-RAM contributes to muscle cell differentiation by regulating PYGM activity. linc-ram glycogen phosphorylase, muscle associated Homo sapiens