Title : Protective effects of a SIRT1 inhibitor on primordial follicle activation and growth induced by cyclophosphamide: insights from a bovine in vitro folliculogenesis system.

Pub. Date : 2022 Apr

PMID : 35247119






2 Functional Relationships(s)
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1 Protective effects of a SIRT1 inhibitor on primordial follicle activation and growth induced by cyclophosphamide: insights from a bovine in vitro folliculogenesis system. Cyclophosphamide sirtuin 1 Bos taurus
2 RESULTS: We found that (1) PM, the main CPM active metabolite, promotes PF activation; (2) the ovarian stress response induced by PM includes a SIRT1-dependent pathway; and (3) EX-527 reduces PF activation and growth induced by PM. phosphoramide mustard sirtuin 1 Bos taurus