Pub. Date : 2022 Mar
PMID : 35187626
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Recycling of SLC38A1 to the plasma membrane by DSCR3 promotes acquired temozolomide resistance in glioblastoma. | Temozolomide | VPS26 endosomal protein sorting factor C | Homo sapiens |
| 2 | Silencing DSCR3 or SLC38A1 expression can increase TMZ sensitivity in MGMT-deficient GBM cells. | Temozolomide | VPS26 endosomal protein sorting factor C | Homo sapiens |
| 3 | Combination of proteomics and in vitro experiments show that DSCR3 directly binds internalized SLC38A1 to mediate its sorting into recycling pathway, which maintains the abundance on plasma membrane and enhances uptake of glutamine in MGMT-deficient GBM cells. | Glutamine | VPS26 endosomal protein sorting factor C | Homo sapiens |
| 4 | CONCLUSIONS: DSCR3 is a crucial regulator of acquired TMZ resistance in MGMT-deficient GBM. | Temozolomide | VPS26 endosomal protein sorting factor C | Homo sapiens |
| 5 | The DSCR3-dependent recycling of SLC38A1 maintains its abundance on plasma membrane, leading to tumor progression and acquired TMZ resistance in MGMT-deficient GBM. | Temozolomide | VPS26 endosomal protein sorting factor C | Homo sapiens |