Title : Inhibition of the Na+/K+-ATPase by cardiac glycosides suppresses expression of the IDO1 immune checkpoint in cancer cells by reducing STAT1 activation.

Pub. Date : 2022 Mar

PMID : 35150740






3 Functional Relationships(s)
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1 Furthermore, NKA inhibition by ouabain and digoxin resulted in increased intracellular Na+ levels and downregulation of IDO1 mRNA and protein levels, which was consistent with the reduction in kynurenine levels. Ouabain tachykinin precursor 1 Homo sapiens
2 Furthermore, NKA inhibition by ouabain and digoxin resulted in increased intracellular Na+ levels and downregulation of IDO1 mRNA and protein levels, which was consistent with the reduction in kynurenine levels. Digoxin tachykinin precursor 1 Homo sapiens
3 Furthermore, NKA inhibition by ouabain and digoxin resulted in increased intracellular Na+ levels and downregulation of IDO1 mRNA and protein levels, which was consistent with the reduction in kynurenine levels. Kynurenine tachykinin precursor 1 Homo sapiens