Pub. Date : 2021
PMID : 34909683
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | SENP2 is vital for optimal insulin signaling and insulin-stimulated glycogen synthesis in human skeletal muscle cells. | Glycogen | SUMO specific peptidase 2 | Homo sapiens |
| 2 | Acute (4 h) oleic acid oxidation was reduced in SENP2-knockdown (SENP2-KD) cells compared to control cells, with no difference in uptake. | Oleic Acid | SUMO specific peptidase 2 | Homo sapiens |
| 3 | After prelabeling (24 h) with oleic acid, total lipid content and incorporation into triacylglycerol was decreased, while incorporation into other lipids, as well as complete oxidation and beta-oxidation was increased in SENP2-KD cells. | Oleic Acid | SUMO specific peptidase 2 | Homo sapiens |
| 4 | Basal glucose uptake (i.e., not under insulin-stimulated conditions) was higher in SENP2-KD cells, whereas oxidation was similar to control myotubes. | Glucose | SUMO specific peptidase 2 | Homo sapiens |
| 5 | Further, basal glycogen synthesis was not different in SENP2-KD myotubes, but both insulin-stimulated glycogen synthesis and AktSer473 phosphorylation was completely blunted in SENP2-KD cells. | Glycogen | SUMO specific peptidase 2 | Homo sapiens |
| 6 | In conclusion, SENP2 plays an important role in fatty acid and glucose metabolism in human myotubes. | Fatty Acids | SUMO specific peptidase 2 | Homo sapiens |