Title : miR-188-3p abolishes germacrone-mediated podocyte protection in a mouse model of diabetic nephropathy in type I diabetes through triggering mitochondrial injury.

Pub. Date : 2022 Jan

PMID : 34847832






2 Functional Relationships(s)
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1 Moreover, germacrone protected against mitochondrial damage, limited reactive oxygen species (ROS) accumulation, and restored glutathione peroxidase (GPX) activity and GPX4 protein expression, subsequently preventing podocyte apoptosis. germacrone glutathione peroxidase 4 Mus musculus
2 CONCLUSION: Germacrone alleviates DN progression in type I diabetes by limiting podocyte apoptosis, which was partly counteracted by miR-188-3p upregulation. germacrone microRNA 188 Mus musculus