Pub. Date : 2022 Jan
PMID : 34715270
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | MicroRNA-214-5p involves in the protection effect of Dexmedetomidine against neurological injury in Alzheimer"s disease via targeting the suppressor of zest 12. | Dexmedetomidine | SUZ12 polycomb repressive complex 2 subunit | Mus musculus |
| 2 | Dexmedetomidine (Dex) has been evidenced to exert neuroprotective effects on multiple neurological diseases, while the function of microRNA(miR)-214-5p on Dex-mediated AD progression via targeting the suppressor of zest 12 (SUZ12) remains unclear. | Dexmedetomidine | SUZ12 polycomb repressive complex 2 subunit | Mus musculus |
| 3 | Dex administration reduced the apoptosis of hippocampal neurons, the contents of serum inflammatory factor and oxidative stress, and attenuated the cognitive impairment of AD mice accompanied by up-regulated miR-214-5p and down-regulated SUZ12, and the overexpression of miR-214-5p or reduction of SUZ12 could effectively enhance the Dex-treated effects on AD mice. | Dexmedetomidine | SUZ12 polycomb repressive complex 2 subunit | Mus musculus |
| 4 | Dex administration reduced the apoptosis of hippocampal neurons, the contents of serum inflammatory factor and oxidative stress, and attenuated the cognitive impairment of AD mice accompanied by up-regulated miR-214-5p and down-regulated SUZ12, and the overexpression of miR-214-5p or reduction of SUZ12 could effectively enhance the Dex-treated effects on AD mice. | Dexmedetomidine | SUZ12 polycomb repressive complex 2 subunit | Mus musculus |
| 5 | Dex administration reduced the apoptosis of hippocampal neurons, the contents of serum inflammatory factor and oxidative stress, and attenuated the cognitive impairment of AD mice accompanied by up-regulated miR-214-5p and down-regulated SUZ12, and the overexpression of miR-214-5p or reduction of SUZ12 could effectively enhance the Dex-treated effects on AD mice. | Dexmedetomidine | SUZ12 polycomb repressive complex 2 subunit | Mus musculus |
| 6 | CONCLUSION: Dex may have a potential neuroprotective effect on AD via the miR-214-5p/SUZ12 axis. | Dexmedetomidine | SUZ12 polycomb repressive complex 2 subunit | Mus musculus |