Title : Low production of 12α-hydroxylated bile acids prevents hepatic steatosis in Cyp2c70-/- mice by reducing fat absorption.

Pub. Date : 2021

PMID : 34626589






7 Functional Relationships(s)
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1 Low production of 12alpha-hydroxylated bile acids prevents hepatic steatosis in Cyp2c70-/- mice by reducing fat absorption. 12alpha-hydroxylated bile acids cytochrome P450, family 2, subfamily c, polypeptide 70 Mus musculus
2 Recently, we generated Cyp2c70-/- mice with a human-like BA composition lacking mouse/rat-specific muricholic acids (MCAs) to accelerate translation from mice to humans. Bile Acids and Salts cytochrome P450, family 2, subfamily c, polypeptide 70 Mus musculus
3 Cyp2c70-deficiency induced a hydrophobic BA pool with high abundances of chenodeoxycholic acid, particularly in females, due to sex-dependent suppression of sterol 12alpha-hydroxylase (Cyp8b1). Bile Acids and Salts cytochrome P450, family 2, subfamily c, polypeptide 70 Mus musculus
4 Cyp2c70-deficiency induced a hydrophobic BA pool with high abundances of chenodeoxycholic acid, particularly in females, due to sex-dependent suppression of sterol 12alpha-hydroxylase (Cyp8b1). Chenodeoxycholic Acid cytochrome P450, family 2, subfamily c, polypeptide 70 Mus musculus
5 Both intestinal cholesterol and fatty acid absorption were reduced in Cyp2c70-/- mice, the latter more strongly in females, despite unaffected biliary BA secretion rates. Cholesterol cytochrome P450, family 2, subfamily c, polypeptide 70 Mus musculus
6 Both intestinal cholesterol and fatty acid absorption were reduced in Cyp2c70-/- mice, the latter more strongly in females, despite unaffected biliary BA secretion rates. Fatty Acids cytochrome P450, family 2, subfamily c, polypeptide 70 Mus musculus
7 The hydrophobic human-like BA pool in Cyp2c70-/- mice prevents WTD-induced obesity in female mice and NAFLD development in both genders, primarily due to impaired intestinal fat absorption. Bile Acids and Salts cytochrome P450, family 2, subfamily c, polypeptide 70 Mus musculus