Pub. Date : 2021
PMID : 34626589
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Low production of 12alpha-hydroxylated bile acids prevents hepatic steatosis in Cyp2c70-/- mice by reducing fat absorption. | 12alpha-hydroxylated bile acids | cytochrome P450, family 2, subfamily c, polypeptide 70 | Mus musculus |
| 2 | Recently, we generated Cyp2c70-/- mice with a human-like BA composition lacking mouse/rat-specific muricholic acids (MCAs) to accelerate translation from mice to humans. | Bile Acids and Salts | cytochrome P450, family 2, subfamily c, polypeptide 70 | Mus musculus |
| 3 | Cyp2c70-deficiency induced a hydrophobic BA pool with high abundances of chenodeoxycholic acid, particularly in females, due to sex-dependent suppression of sterol 12alpha-hydroxylase (Cyp8b1). | Bile Acids and Salts | cytochrome P450, family 2, subfamily c, polypeptide 70 | Mus musculus |
| 4 | Cyp2c70-deficiency induced a hydrophobic BA pool with high abundances of chenodeoxycholic acid, particularly in females, due to sex-dependent suppression of sterol 12alpha-hydroxylase (Cyp8b1). | Chenodeoxycholic Acid | cytochrome P450, family 2, subfamily c, polypeptide 70 | Mus musculus |
| 5 | Both intestinal cholesterol and fatty acid absorption were reduced in Cyp2c70-/- mice, the latter more strongly in females, despite unaffected biliary BA secretion rates. | Cholesterol | cytochrome P450, family 2, subfamily c, polypeptide 70 | Mus musculus |
| 6 | Both intestinal cholesterol and fatty acid absorption were reduced in Cyp2c70-/- mice, the latter more strongly in females, despite unaffected biliary BA secretion rates. | Fatty Acids | cytochrome P450, family 2, subfamily c, polypeptide 70 | Mus musculus |
| 7 | The hydrophobic human-like BA pool in Cyp2c70-/- mice prevents WTD-induced obesity in female mice and NAFLD development in both genders, primarily due to impaired intestinal fat absorption. | Bile Acids and Salts | cytochrome P450, family 2, subfamily c, polypeptide 70 | Mus musculus |