Pub. Date : 2022 May
PMID : 34591986
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | METHODS & RESULTS: We demonstrated that mice with Otub1 deficiency exhibited aggravated high-fat diet (HFD)- and high-fat high-cholesterol (HFHC) diet-induced hyperinsulinemia and liver steatosis. | Cholesterol | OTU domain, ubiquitin aldehyde binding 1 | Mus musculus |
| 2 | Through immunoprecipitation-mass spectrometry (IP-MS) analysis, we further found that OTUB1 directly bound to tumor necrosis factor receptor-associated factor 6 (TRAF6) and suppressed its lysine 63 (K63)-linked polyubiquitination, thus inhibiting the activation of ASK1 and its downstream pathway. | Lysine | OTU domain, ubiquitin aldehyde binding 1 | Mus musculus |