Pub. Date : 2021 Sep 20
PMID : 34572598
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The Effect of a Synthetic Estrogen, Ethinylestradiol, on the hERG Block by E-4031. | E 4031 | ETS transcription factor ERG | Homo sapiens |
| 2 | We previously reported that physiological concentrations of some estrogens partially suppress the hERG channel currents by interacting with the S6 residue F656 and increase the sensitivity of hERG blockade by E-4031. | E 4031 | ETS transcription factor ERG | Homo sapiens |
| 3 | We previously reported that physiological concentrations of some estrogens partially suppress the hERG channel currents by interacting with the S6 residue F656 and increase the sensitivity of hERG blockade by E-4031. | E 4031 | ETS transcription factor ERG | Homo sapiens |
| 4 | On the other hand, EE2 at therapeutic concentrations reduced the degree of hERG current suppression by E-4031. | E 4031 | ETS transcription factor ERG | Homo sapiens |
| 5 | The administration of EE2 followed by E-4031 blockade reversed the current suppression, suggesting that the interaction of EE2 and E-4031 alters hERG at the drug-binding site. | E 4031 | ETS transcription factor ERG | Homo sapiens |
| 6 | The administration of EE2 followed by E-4031 blockade reversed the current suppression, suggesting that the interaction of EE2 and E-4031 alters hERG at the drug-binding site. | E 4031 | ETS transcription factor ERG | Homo sapiens |