Pub. Date : 2021 Aug 15
PMID : 34512893
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Receiver operator characteristic (ROC) analysis was conducted to analyze the diagnostic value of serum miR-129-5p in patients with DM or DMCs. | Chlorodimethylsilane | microRNA 1295a | Homo sapiens |
| 2 | RESULTS: There was a 4.378-fold and 7.369-fold increase in serum miR-129-5p expression in the DM (5.346 +- 0.405) and DMCs (8.998 +- 0.631) groups, respectively (P < 0.001), compared with the control group (1.221+-0.090). | Chlorodimethylsilane | microRNA 1295a | Homo sapiens |
| 3 | In addition, the expression of serum miR-129-5p in patients with DMCs was higher than that in patients with DM, revealing a 1.683-fold increase (P < 0.001). | Chlorodimethylsilane | microRNA 1295a | Homo sapiens |
| 4 | Additionally, serum miR-129-5p expression significantly correlated with smoking history, disease duration, and glycated hemoglobin (HbA1c) in patients with DMCs (P < 0.001). | Chlorodimethylsilane | microRNA 1295a | Homo sapiens |
| 5 | The area under the ROC curve (AUC) of miR-129-5p as a serum marker was 0.964 (95% confidence interval (CI): 0.930-0.997, P < 0.001) in distinguishing between patients with DM and healthy controls, whereas the AUC of miR-129-5p as a serum marker was 0.979 (95%CI: 0.959-0.999, P < 0.001) in distinguishing between patients with DMCs and healthy controls. | Chlorodimethylsilane | microRNA 1295a | Homo sapiens |
| 6 | The area under the ROC curve (AUC) of miR-129-5p as a serum marker was 0.964 (95% confidence interval (CI): 0.930-0.997, P < 0.001) in distinguishing between patients with DM and healthy controls, whereas the AUC of miR-129-5p as a serum marker was 0.979 (95%CI: 0.959-0.999, P < 0.001) in distinguishing between patients with DMCs and healthy controls. | Chlorodimethylsilane | microRNA 1295a | Homo sapiens |
| 7 | CONCLUSION: Elevated serum miR-129-5p expression levels correlate with the development of DMCs and can be utilized as a novel early diagnostic biomarker for DM combined with macrovascular complications. | Chlorodimethylsilane | microRNA 1295a | Homo sapiens |