Pub. Date : 2021 Oct 26
PMID : 34478523
14 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sphingomyelin synthase 1 (SMS1) contributes to the generation of membrane sphingomyelin (SM) and affects SM-mediated physiological functions. | Sphingomyelins | sphingomyelin synthase 1 | Mus musculus |
| 2 | Sphingomyelin synthase 1 (SMS1) contributes to the generation of membrane sphingomyelin (SM) and affects SM-mediated physiological functions. | Sphingomyelins | sphingomyelin synthase 1 | Mus musculus |
| 3 | Sphingomyelin synthase 1 (SMS1) contributes to the generation of membrane sphingomyelin (SM) and affects SM-mediated physiological functions. | Sphingomyelins | sphingomyelin synthase 1 | Mus musculus |
| 4 | Sphingomyelin synthase 1 (SMS1) contributes to the generation of membrane sphingomyelin (SM) and affects SM-mediated physiological functions. | Sphingomyelins | sphingomyelin synthase 1 | Mus musculus |
| 5 | Sphingomyelin synthase 1 (SMS1) contributes to the generation of membrane sphingomyelin (SM) and affects SM-mediated physiological functions. | Sphingomyelins | sphingomyelin synthase 1 | Mus musculus |
| 6 | Sphingomyelin synthase 1 (SMS1) contributes to the generation of membrane sphingomyelin (SM) and affects SM-mediated physiological functions. | Sphingomyelins | sphingomyelin synthase 1 | Mus musculus |
| 7 | Deficiency of SMS1, but not SMS2, prevented SM production and enhanced phosphatidylserine (PS) externalization on the plasma membranes of platelets and megakaryocytes. | Sphingomyelins | sphingomyelin synthase 1 | Mus musculus |
| 8 | Deficiency of SMS1, but not SMS2, prevented SM production and enhanced phosphatidylserine (PS) externalization on the plasma membranes of platelets and megakaryocytes. | Phosphatidylserines | sphingomyelin synthase 1 | Mus musculus |
| 9 | Deficiency of SMS1, but not SMS2, prevented SM production and enhanced phosphatidylserine (PS) externalization on the plasma membranes of platelets and megakaryocytes. | Phosphatidylserines | sphingomyelin synthase 1 | Mus musculus |
| 10 | Multimer formation in the plasma membrane of TMEM16F, a known calcium (Ca2+)-activated nonselective ion channel and Ca2+-dependent PS scramblase, was enhanced, resulting in PS externalization to outer-leaflets through increased Ca2+ influx in immortalized mouse embryonic fibroblasts established from SMS1-KO mice (SMS1-KO tMEFs), as seen with SMS1-KO platelets. | Calcium | sphingomyelin synthase 1 | Mus musculus |
| 11 | Multimer formation in the plasma membrane of TMEM16F, a known calcium (Ca2+)-activated nonselective ion channel and Ca2+-dependent PS scramblase, was enhanced, resulting in PS externalization to outer-leaflets through increased Ca2+ influx in immortalized mouse embryonic fibroblasts established from SMS1-KO mice (SMS1-KO tMEFs), as seen with SMS1-KO platelets. | Calcium | sphingomyelin synthase 1 | Mus musculus |
| 12 | SMS1-KO tMEFs in which TMEM16F was knocked out using the CRISPR-Cas9 system lacked both the Ca2+ influx and excess PS exposure seen in SMS1-KO tMEFs. | Phosphatidylserines | sphingomyelin synthase 1 | Mus musculus |
| 13 | Therefore, SM depletion on platelet membrane microdomains due to SMS1 deficiency enhanced PS externalization via a Ca2+ influx through TMEM16F activation, leading to elevated platelet clearance and causing hemostasis dysfunction through thrombocytopenia. | Sphingomyelins | sphingomyelin synthase 1 | Mus musculus |
| 14 | Therefore, SM depletion on platelet membrane microdomains due to SMS1 deficiency enhanced PS externalization via a Ca2+ influx through TMEM16F activation, leading to elevated platelet clearance and causing hemostasis dysfunction through thrombocytopenia. | Phosphatidylserines | sphingomyelin synthase 1 | Mus musculus |