Title : Effects of 1α,25-Dihydroxyvitamin D3 on the Pharmacokinetics of Procainamide and Its Metabolite N-Acetylprocainamide, Organic Cation Transporter Substrates, in Rats with PBPK Modeling Approach.

Pub. Date : 2021 Jul 25

PMID : 34452094






1 Functional Relationships(s)
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1 A physiological model for the pharmacokinetics of PA and NAPA in rats was useful for linking changes in the transcriptional and translational expressions of rOCTs and rMATE1 transporters to the altered pharmacokinetics of the drugs. Acecainide solute carrier family 47 member 1 Rattus norvegicus