Title : Mechanisms Mediating the Regulation of Peroxisomal Fatty Acid Beta-Oxidation by PPARα.

Pub. Date : 2021 Aug 20

PMID : 34445672






2 Functional Relationships(s)
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1 The ligand-activated heterodimer PPARalpha/RXRalpha recognizes a DNA sequence, called PPRE (Peroxisome Proliferator Response Element), corresponding to two half-consensus hexanucleotide motifs, AGGTCA, separated by one nucleotide. hexanucleotide retinoid X receptor alpha Homo sapiens
2 Accordingly, the assembled complex containing PPRE/PPARalpha/RXRalpha/ligands/Coregulators controls the expression of the genes involved in liver peroxisomal fatty acid beta-oxidation. Fatty Acids retinoid X receptor alpha Homo sapiens