Title : Lidocaine prevents breast cancer growth by targeting neuronatin to inhibit nerve fibers formation.

Pub. Date : 2021

PMID : 34193770






5 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Lidocaine prevents breast cancer growth by targeting neuronatin to inhibit nerve fibers formation. Lidocaine neuronatin Mus musculus
2 The results showed that lidocaine treatment effectively inhibited tumor growth and nerve fiber formation, and down-regulated the expression levels of protein gene product 9.5, neurofilament, nerve growth factor (NGF), and neuronatin (Nnat). Lidocaine neuronatin Mus musculus
3 The results showed that lidocaine treatment effectively inhibited tumor growth and nerve fiber formation, and down-regulated the expression levels of protein gene product 9.5, neurofilament, nerve growth factor (NGF), and neuronatin (Nnat). Lidocaine neuronatin Mus musculus
4 Overexpression NGF and Nnat both could reverse the therapeutic effects of lidocaine. Lidocaine neuronatin Mus musculus
5 These results suggest that the effect of lidocaine on inhibiting breast cancer invasion and metastasis may be achieved by targeting Nnat, regulating the production of NGFs in cancer cells, and subsequently inhibiting the formation of nerve fibers. Lidocaine neuronatin Mus musculus