Pub. Date : 2021 Nov
PMID : 34182632
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Selective interaction of microcystin congeners with zebrafish (Danio rerio) Oatp1d1 transporter. | microcystin | solute carrier organic anion transporter family, member 1D1 | Danio rerio |
| 2 | In this study, six MC congeners of varying physicochemical properties (MC-LR, -RR, -YR, -LW, -LF, -LA) were tested by measuring their effect on the uptake of model Oatp1d1 fluorescent substrate Lucifer yellow (LY) in HEK293T cells transiently or stably overexpressing zebrafish Oatp1d1. | microcystin | solute carrier organic anion transporter family, member 1D1 | Danio rerio |
| 3 | Finally, apart from determination of the chemical composition of cynobacterial blooms, a reliable risk assessment should take into account the interaction of identified MC congeners with Oatp1d1 as their primary transporter, and herewith we demonstrated that such a comprehensive approach could be based on the use of highly specific in vitro models, accompanied by chemical assessment and in silico molecular docking studies. | microcystin | solute carrier organic anion transporter family, member 1D1 | Danio rerio |