Pub. Date : 2021 Oct
PMID : 34142331
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Our results showed that pharmacologically activating RXR-alpha with bexarotene significantly accelerated hematoma clearance and alleviated neurological dysfunction after ICH. | Bexarotene | retinoid X receptor alpha | Homo sapiens |
| 2 | Mechanistically, bexarotene promoted the nuclear translocation of RXR-alpha and PPAR-gamma, as well as reducing neuroinflammation by modulating microglia/macrophage reprograming from the M1 into the M2 phenotype. | Bexarotene | retinoid X receptor alpha | Homo sapiens |
| 3 | Furthermore, all the beneficial effects of RXR-alpha in ICH were reversed by the PPAR-gamma inhibitor GW9662. | 2-chloro-5-nitrobenzanilide | retinoid X receptor alpha | Homo sapiens |