Pub. Date : 2022 Feb 1
PMID : 34134472
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | While defining the domains of RXRA that are required for anti-leukemic effects in mouse KMT2A-MLLT3 leukemia cells, we unexpectedly identified RXRA DT448/9PP as a constitutively active variant capable of inducing maturation and loss of their proliferative phenotype. | dt448 | retinoid X receptor alpha | Homo sapiens |
| 2 | While defining the domains of RXRA that are required for anti-leukemic effects in mouse KMT2A-MLLT3 leukemia cells, we unexpectedly identified RXRA DT448/9PP as a constitutively active variant capable of inducing maturation and loss of their proliferative phenotype. | (S)-PMPDAP | retinoid X receptor alpha | Homo sapiens |
| 3 | RXRA DT448/9PP was associated with ligand-independent activity in reporter assays, with enhanced co-activator interactions, reduced engraftment in vivo, and activation of myeloid maturation transcriptional signatures that overlapped with cells treated with the potent RXRA agonist bexarotene, suggestive of constitutive activity that leads to leukemic maturation. | Bexarotene | retinoid X receptor alpha | Homo sapiens |