Pub. Date : 2021 Sep
PMID : 34110073
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sex-specific role for prefrontal cortical protein interacting with C kinase 1 in cue-induced cocaine seeking. | Cocaine | protein interacting with C kinase 1 | Mus musculus |
| 2 | Consistent with our hypothesis that disruption of PICK1 in the mPFC would lead to a decrease in addiction-like behaviour, we found that conditional deletion of PICK1 in the mPFC attenuates cue-induced cocaine seeking in male mice. | Cocaine | protein interacting with C kinase 1 | Mus musculus |
| 3 | However, prefrontal PICK1 deletion had the opposite effect in females, leading to an increase in cue-induced reinstatement of cocaine seeking. | Cocaine | protein interacting with C kinase 1 | Mus musculus |