Pub. Date : 2021 May 13
PMID : 33986260
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We hypothesized that GA significantly alleivates D-GalN/LPS-induced ALI, which involved in PXR-mediated autophagy and lysosome biogenesis. | 18alpha-glycyrrhetinic acid | nuclear receptor subfamily 1, group I, member 2 | Mus musculus |
| 2 | Simultaneously, GA markedly activates PXR, even reversing the D-GalN/LPS-induced reduction of PXR and its downstream genes. | 18alpha-glycyrrhetinic acid | nuclear receptor subfamily 1, group I, member 2 | Mus musculus |
| 3 | Simultaneously, GA markedly activates PXR, even reversing the D-GalN/LPS-induced reduction of PXR and its downstream genes. | 18alpha-glycyrrhetinic acid | nuclear receptor subfamily 1, group I, member 2 | Mus musculus |
| 4 | In contrast, GA has a weak protective effect in pharmacological inhibition of PXR and PXR-null mice, which significantly affected apoptosis- and autophagy-related genes. | 18alpha-glycyrrhetinic acid | nuclear receptor subfamily 1, group I, member 2 | Mus musculus |
| 5 | In contrast, GA has a weak protective effect in pharmacological inhibition of PXR and PXR-null mice, which significantly affected apoptosis- and autophagy-related genes. | 18alpha-glycyrrhetinic acid | nuclear receptor subfamily 1, group I, member 2 | Mus musculus |
| 6 | PXR knockout interferes with the stability of autophagosomes and lysosomes, preventing GA reducing the expression of lysosomal genes such as Cst B and TPP1, and suppressing autophagy flow. | 18alpha-glycyrrhetinic acid | nuclear receptor subfamily 1, group I, member 2 | Mus musculus |
| 7 | Therefore, we believe that GA increases autophagy by inhibiting autophagosome-lysosome fusion and blocked autophagy flux via activation of PXR. | 18alpha-glycyrrhetinic acid | nuclear receptor subfamily 1, group I, member 2 | Mus musculus |
| 8 | In conclusion, our results show that GA activates PXR to regulate autophagy and lysosome biogenesis, represented by inhibiting autophagosome-lysosome fusion and stabilization of lysosome. | 18alpha-glycyrrhetinic acid | nuclear receptor subfamily 1, group I, member 2 | Mus musculus |
| 9 | These results identify a new mechanism by which GA-dependent PXR activation reduces D-GalN/LPS-induced acute liver injury. | 18alpha-glycyrrhetinic acid | nuclear receptor subfamily 1, group I, member 2 | Mus musculus |