Title : A synthetically lethal nanomedicine delivering novel inhibitors of polynucleotide kinase 3'-phosphatase (PNKP) for targeted therapy of PTEN-deficient colorectal cancer.

Pub. Date : 2021 Jun 10

PMID : 33933518






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1 Here, we report on the in vitro and in vivo evaluation of a nano-encapsulated potent, but poorly water-soluble lead PNKP inhibitor, namely A83B4C63, as a new targeted therapeutic for PTEN-deficient CRC. Water polynucleotide kinase 3'- phosphatase Mus musculus