Title : Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors.

Pub. Date : 2021 Apr 9

PMID : 33833118






1 Functional Relationships(s)
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1 We show that inhibition of DNPH1, a protein that eliminates cytotoxic nucleotide 5-hydroxymethyl-deoxyuridine (hmdU) monophosphate, potentiates the sensitivity of BRCA-deficient cells to PARP inhibitors (PARPi). nucleotide 5-hydroxymethyl-deoxyuridine (hmdu) monophosphate 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 Homo sapiens