Pub. Date : 2021
PMID : 33816278
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CMPK1 Regulated by miR-130b Attenuates Response to 5-FU Treatment in Gastric Cancer. | Fluorouracil | microRNA 130b | Homo sapiens |
| 2 | Further analysis demonstrated that miR-130b as a key epigenetic regulator of CMPK1, and miR-130b-mediated attenuation of CMPK1 resulted in resistance of gastric cancer cells to DNA damage and cell death after treatment with 5-FU. | Fluorouracil | microRNA 130b | Homo sapiens |
| 3 | Further analysis demonstrated that miR-130b as a key epigenetic regulator of CMPK1, and miR-130b-mediated attenuation of CMPK1 resulted in resistance of gastric cancer cells to DNA damage and cell death after treatment with 5-FU. | Fluorouracil | microRNA 130b | Homo sapiens |
| 4 | Thus, this newly identified miR-130b-CMPK1 axis suggests a potentially new chemotherapeutic strategy for improved response to 5-FU therapy. | Fluorouracil | microRNA 130b | Homo sapiens |